Link Between C-reactive Proteins and Depression Found

Researchers at Copenhagen University Hospital and Herlev Hospital found evidence that people who have higher levels of C-reactive protein –an precursor to inflammation- have a higher risk of depression.

What are C-Reactive Proteins?

Produced by the liver, C-reactive proteins are present in the blood stream and rise when the body is experiencing inflammation. C-reactive proteins bind to phosphocholine, a molecule released by dead or damaged cells. A C-reactive protein (CRP) level above 10 miligrams per liter of blood may be a sign of an inflammatory disease such as cancer, cardiovascular disease, arthritis or other types of infection.

The Study:

The study, published in the Archives of General Psychiatry, included 73,131 subjects from Denmark between the ages of 20 and 100. Subjects were given 2-single item self-reports to ascertain their medical history and current researchers found the higher the C-reactive protein levels, the higher the odds of also being prescribed antidepressants, abusing antidepressants, or being hospitalized because of depression.

Scientists noted that only a correlation was identified- not a cause and effect situation- and that more research must be done to explain this association.

However, past research also suggests a potential link between depression and inflammation. Researchers at Michigan State University found that levels of a brain chemical called quinolinic acid, which is a byproduct caused by inflammation, are elevated in people who are severely depressed or suicidal.

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Magnesium Depletion and Chronic Disease

For reasons that elude me (perhaps it’s because calcium is the most common mineral in the human body), calcium has historically been the primary dietary mineral that has received the most attention in both medical research and the mainstream media. Over the last couple of years however, the mineral magnesium has quickly been the focus of intense scientific study, recently culminating with the latest report that suggests that magnesium may be just as important, if not more so, to children’s bone health than calcium.
While magnesium is the fourth most abundant mineral in the body, it is needed for more than 300 biochemical reactions.  It is involved in supporting proper nerve function and a healthy immune system. It helps keep heart rhythm steady and bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, and is involved in energy metabolism and protein synthesis.
The metabolism of carbohydrates and fats to produce energy (which includes ATP production) requires numerous magnesium-dependent chemical reactions. Magnesium is also required for a number of steps during DNA and RNA synthesis. Glutathione, an important antioxidant, requires magnesium for its production.
Only 1% of magnesium is found in the blood, the rest being bound in the tissues and bones. Therefore the mineral is hard to test for and as a result, magnesium deficiency can be difficult to detect. Symptoms of magnesium deficiency can be varied and potentially fool even the best clinician. Insomnia, irritability, nervousness, fatigue, anorexia, muscle twitching, abnormal heart beat and poor memory are some of the signs.  When you take into consideration the myriad functions magnesium performs and the multiple systems the mineral affects, a magnesium deficiency can affect virtually every system of the body. Magnesium deficiency has even been associated with epilepsy and M.S.
Additionally, if you look closely at the symptoms of magnesium deficiency and apply some of them to a child, would this not describe symptoms of ADHD?
Magnesium deficiency has also been shown to be a predictor of both diabetes and heart disease, providing some direct evidence that greater intake of dietary magnesium may have a long-term protective effect on lowering risk in both conditions or, in the case of its long term, chronic depletion/deficiency, directly participate in the development of both conditions.
In the case of diabetes, it is suggested that insulin resistance can be directly related to long-term magnesium exhaustion while in cardiovascular heath, hypertension and endothelial dysfunction appear to be associated with chronic decline as well.
Finally, several studies have shown an increased cancer rate in regions with low magnesium levels in soil and drinking water (the same for selenium). In Egypt, the cancer rate was only about 10% of that in Europe and America. The main difference was an extremely high magnesium intake of 2.5 to 3g in these cancer-free populations, ten times more than in most western countries.
In the face of magnesium’s incredible importance in human health, it goes without saying that the possible deficiency of this mineral in the clinical setting may need to be more closely scrutinized, as the consequences could be quite impactful.
Michael Fuhrman, D. C.

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Did you know a vitamin D deficiency more than DOUBLES your risk of type II diabetes?

Just a few years ago, vitamin D was simply known as the “bone vitamin.” Thanks to the hard work of many scientists, especially Michael Holick, MD, a pioneer in vitamin D research, the data show that nearly every tissue and cell type in the body has receptors for vitamin D. As a result of this discovery, much higher doses are required for optimal functioning. This discovery has radically changed how we understand the role of vitamin D in the body.

            Unless you body is at optimal levels, you are opening the door to a host of disorders, ranging from heart disease and Alzheimer’s to weak bodes and diabetes.

            In fact, even if you have normal blood sugar today, a vitamin D deficiency makes you 91% more likely to progress to insulin resistance, or “pre-diabetes,” and it more than doubles your risk from progressing to active, type II diabetes.

            Unfortunately, vitamin D deficiency is a global epidemic. An estimated 1 billion people do not have adequate vitamin D levels. And 64% of Americans don’t have enough vitamin D to keep all of their tissues operating at peak capacity.

            The results of this deficiency are catastrophic. Studies have now shown that vitamin D deficiency is associated with increased risk of a long list of diseases that span all systems of the body. In fact, low levels of vitamin D increase the risk of non-Alzheimer’s dementia almost 20 times!

            While checking for vitamin D levels is still not standard care for many physicians, you will realize from reading this article that assessing vitamin D status is one of the most important health protecting steps you can take. Fortunately, achieving optimal levels of vitamin D is easy, inexpensive, and highly protective against a range of lethal diseases. 

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Critically Ill Have Reduced Levels of CoQ10

An article published in the Journal of Critical Care revealed lower levels of coenzyme Q10 (CoQ10) in critically ill patients in comparison with healthy men and women.* The study compared 36 adult intensive care unit patients with 18 healthy controls. Septic shock was present in 12 of the critically ill subjects. While the lowest levels of plasma CoQ10 occurred in septic shock patients, levels were lower in critically ill patients both with and without septic shock in comparison with healthy subjects. Reduced levels of CoQ10 were also associated with increased age and with a decline in the ability to perform activities of daily living after hospital discharge. Authors Andrea Coppadoro and colleagues remark that CoQ10 supplementation has been associated with improvement in activities of daily living scores, neuromuscular function, and other long-term outcomes in certain groups, suggesting that supplementation could also benefit the outcome of the critically ill. —D. Dye

Reference

* J Crit Care. 2013 Apr 22. To purchase, CLICK HERE: http://isotonix.marketamerica.com/knapp/USA/Search/Product/2250